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Journal of Antimicrobial Chemotherapy (2000) 46, 391-395
© 2000 The British Society for Antimicrobial Chemotherapy

Intrinsic resistance of Mycobacterium tuberculosis to clarithromycin is effectively reversed by subinhibitory concentrations of cell wall inhibitors

Suzana Bosne-David*, Vanessa Barros, Sandra Cabo Verde, Clara Portugal and Hugo L. David

Centro de Malária e outras Doenças Tropicais, Instituto de Higiéne e Medicina Tropical, Universidade Nova de Lisboa, Portugal

Subinhibitory concentrations of bacitracin, vancomycin and other inhibitors of cell wall synthesis reversed to varying extents the intrinsic resistance of Mycobacterium tuberculosis to clarithromycin. Ethambutol reversed clarithromycin resistance in all of the M. tuberculosis strains studied regardless of their susceptibility to this drug.

* Corresponding author. Tel. and Fax: +351-(1)362-24-58; E-mail: suzanadavid{at}ihmt.unl.pt


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