Journal of Antimicrobial Chemotherapy (2000) 46, 319-322
© 2000 The British Society for Antimicrobial Chemotherapy
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Concentrations of single-dose meropenem (1 g iv) in bronchoalveolar lavage and epithelial lining fluid
Departments of a Infectious Diseases and b Respiratory Medicine, University and Hospital of Verona, Verona; c Department of Infectious Diseases, University of Torino, Torino; d B. T. Biotecnica, Varese; e Medical Direction, Zeneca, Milano; f Department of Infectious Diseases, Hospital of Asti, Italy
The concentrations of meropenem were measured in plasma, bronchoalveolar lavage (BAL) and epithelial lining fluid (ELF) 0.5–8 h after the administration of a single 1 g iv dose of meropenem. Thirty-five patients undergoing bronchoscopy were studied. Mean concentrations in plasma, BAL and ELF, respectively, measured by high performance liquid chromatography, were as follows: 0.5 h: 25.96, 0.14, 5.04 mg/L; 1 h: 14.98, 0.09, 7.07 mg/L; 2 h: 12.01, 0.06, 3.86 mg/L; 4 h: 2.51, 0.04, 2.20 mg/L; 6 h: 0.57, 0, 0.59 mg/L; 8 h: 0.29, 0, 0 mg/L. Throughout the 2 h following infusion, concentrations in ELF exceeded the MIC90 for all nosocomial and community-acquired respiratory pathogens, including Pseudomonas aeruginosa (3.05 mg/L), Haemophilus influenzae (0.16 mg/L) and penicillin-resistant Streptococcus pneumoniae (0.86 mg/L). These results support the clinical efficacy of meropenem in the treatment of a wide range of pulmonary infections.
* Correspondence address. Divisione Clinicizzata di Malattie Infettive, Ospedale Civile Maggiore, Piazzale Stefani No. 1, 37126 Verona, Italy. Tel: +39-045-8072390/8073389; Fax: +39-045-8340223; E-mail: benealle{at}yahoo.com
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