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Journal of Antimicrobial Chemotherapy (2000) 46, 269-271
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Investigation of the anti-inflammatory and membrane-stabilizing potential of spiramycin in vitro

A. J. Therona,*, C. Feldmanb and R. Andersona

a Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Institute for Pathology, University of Pretoria, PO Box 2034, Pretoria 0001; b Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa

The effects of the 16-member macrolide spiramycin (2.5–80 mg/L) and the 14-member agent clarithromycin on the production of superoxide by activated human neutrophils were compared in vitro and related to membrane-stabilizing activity. Superoxide production was measured by lucigenin-enhanced chemiluminescence with N-formyl-L-methionyl-L-leucyl-L-phenylalanine (1 µM) as the stimulus, and membrane-stabilizing activity was measured by a haemolytic procedure. Clarithromycin, but not spiramycin, caused dose-related inhibition of superoxide production by activated neutrophils and also protected erythrocytes against haemolysis, while spiramycin possessed only weak membrane-stabilizing activity. These observations underscore the apparent association between the anti-inflammatory and membrane-stabilizing properties of macrolides.

* Corresponding author. Tel: +27-12-3192425; Fax: +27-12-3230727.


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