Journal of Antimicrobial Chemotherapy (2000) 46, 133-136
© 2000 The British Society for Antimicrobial Chemotherapy
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Antibiotic susceptibility and mechanisms of ß-lactam resistance in 1310 strains of Pseudomonas aeruginosa: a French multicentre study (1996)
a Hôpital d'Instruction des Armées Bégin, 69 Avenue de Paris, 94163 St Mandé; b Laboratoires Glaxo-Wellcome, 100 route de Versailles, 78163 Marly le Roi; c Hôpital Ambroise Paré, 9 avenue Charles de Gaulle, 92104 Boulogne; d 50 rue Corvisart, 75013 Paris, France
A total of 1310 consecutive strains of Pseudomonas aeruginosa were collected in 11 French hospitals in 1996. The percentages of susceptible isolates measured by the agar dilution method were: ticarcillin (53%), piperacillin (69%) (MIC 16 mg/L), ceftazidime (77%), cefepime (55%), cefpirome (40%), aztreonam (57.5%), imipenem (81.5%) (MIC 4 mg/L), amikacin (64.5%) (MIC 8 mg/L) and ciprofloxacin (58%) (MIC 1 mg/L). Resistance to ß-lactams was linked to the production of transferable ß-lactamases (30%), overproduction of cephalosporinase (29%) and to non-enzymic mechanisms (38%).
* Corresponding author. Tel: +33-1439-85336; E-mail: beginbio{at}club-internet.fr
Groupe d'Etude de la Résistance de Pseudomonas aeruginosa aux Bêtalactamines (Workgroup on the resistance of Pseudomonas aeruginosa to ß-lactam antibiotics), Paris, France: J. L. Avril (Rennes), C. Bébéar (Bordeaux), R. Cluzel, J. Sirot (Clermont-Ferrand), J. Etienne (Lyon), H. Monteil, J. M. Scheftel (Strasbourg), C. Morel, R. Leclercq (Caen), A. Andremont (Paris-Bichat), V. Jarlier (Paris-Salpetrière), A. Philippon (Paris-Saint-Louis).
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