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Journal of Antimicrobial Chemotherapy (2000) 46, 121-123
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Resistance of Helicobacter pylori to metronidazole, tetracycline and amoxycillin

H. Wu*, X. D. Shi, H. T. Wang and J. X. Liu

Department of Microbiology, Shanghai Second Medical University, Chongqing South Road 280, Shanghai, China 200025

Resistance to metronidazole, tetracycline and amoxycillin, and ß-lactamase production were determined for 153 clinical isolates of Helicobacter pylori. Of these isolates, 77.8% were resistant to metronidazole (MIC > 8 mg/L), 58.8% to tetracycline (MIC > 16 mg/L) and 71.9% to amoxycillin (MIC > 0.5 mg/L); 39.2% were multiresistant. Resistance to metronidazole was more common in isolates from females than in those from males (P < 0.05). None of the isolates produced ß-lactamase, so the mechanism of amoxycillin resistance was not linked to production of ß-lactamase.

* Corresponding author. Tel: +86-21-64158540; Fax: +86-21-63842916; E-mail: wu4hong{at}263.net


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