Journal of Antimicrobial Chemotherapy (2000) 46, 1-6
© 2000 The British Society for Antimicrobial Chemotherapy
Leading articles |
New insights into the mechanism of action of lantibiotics—diverse biological effects by binding to the same molecular target
a Bayer AG, PH-Research Antiinfectives I, D-42096 Wuppertal; b Institute of Medical Microbiology and Immunology, University of Bonn, D-53105 Bonn, Germany
The spread of bacterial resistance leads to a growing demand for novel antibiotics. However, despite significant efforts in academia and the pharmaceutical industry, no genuinely new class of antibacterial compounds has reached the market for almost 20 years.
Industrial strategies for searching for antibiotics with novel mechanisms of action include the screening of large ‘libraries' of synthetic compounds for inhibitors of targets that have not yet been exploited in antibacterial chemotherapy. The advantage of this approach is that it leads to compounds of low molecular mass which are relatively easy to modify by medicinal chemistry. On the other hand, such ‘hits' obtained from in vitro assays still have to overcome major obstacles, e.g. penetration into the intact bacterial cell, an appropriate antibacterial spectrum, favourable pharmacokinetics and low toxicity, before they can be marketed. Therefore, other approaches, such as a detailed evaluation of the potential of existing classes of antimicrobial compounds,
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