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Journal of Antimicrobial Chemotherapy (2000) 45, 899-901
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

In vitro activity of meropenem, imipenem, cefepime and ceftazidime against Pseudomonas aeruginosa isolates from cystic fibrosis patients

John C. Christensona,*, E. Kent Korgenskib and Judy A. Dalyb,c

a Department of Paediatrics, Division of Infectious Diseases and Geographic Medicine, b Clinical Microbiology Laboratory, Primary Children's Medical Center and c Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA

We studied 67 Pseudomonas aeruginosa isolates from cystic fibrosis patients, and compared their in vitro susceptibility to two carbapenems (meropenem and imipenem) and two cephalosporins (cefepime and ceftazidime). The carbapenems were more effective in vitro than the cephalosporins: 92.5% of isolates were susceptible to the former and 77.6% to the latter. Essentially no difference was found between meropenem and imipenem. More discrepancies were seen between cefepime and ceftazidime: four of 67 isolates (6.0%) were more susceptible to cefepime than to ceftazidime, while eight (11.9%) were more susceptible to ceftazidime than to cefepime.

* Correspondence address. University of Utah School of Medicine, Department of Paediatrics, Division of Infectious Diseases and Geographic Medicine, 50 North Medical Drive, Room 2R022, Salt Lake City, UT 84132, USA. Tel: +1-801-581-6791; Fax: +1-801-585-3789; E-mail: john.c.christenson{at}hsc.utah.edu


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T. Schulin
In vitro activity of the aerosolized agents colistin and tobramycin and five intravenous agents against Pseudomonas aeruginosa isolated from cystic fibrosis patients in southwestern Germany
J. Antimicrob. Chemother., February 1, 2002; 49(2): 403 - 406.
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