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Journal of Antimicrobial Chemotherapy (2000) 45, 681-684
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Accumulation of KRM-1648 by Mycobacterium aurum and Mycobacterium tuberculosis

Laura J. V. Piddock* and Vito Ricci

Antimicrobial Agents Research Group, Division of Immunity and Infection, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK

After exposure to 2 mg/L 14C-labelled KRM-1648 (a new broad-spectrum benzoxazinorifamycin antibiotic) for 5 min, a steady-state concentration of 31.3 ± 3 ng/mg cells KRM-1648 and 12.6 ± 0.3 ng/mg cells KRM-1648 was accumulated by wild-type antibiotic-susceptible Mycobacterium aurum (A+) and Mycobacterium tuberculosis (H37Rv), respectively. However, 2 mg/L KRM-1648 was bactericidal for M. tuberculosis. A steady-state concentration of 3.7 ± 0.1 ng/mg cells KRM-1648 was accumulated after exposure to 0.5 mg/L. At pH 4 higher concentrations were accumulated than at pH 7. A sub-inhibitory concentration of ethambutol increased the concentration of KRM-1648 accumulated, but Tween 80 and reserpine had little or no effect.

* Tel: +44-121-414-6969; Fax: +44-121-414-6966; E-mail: l.j.v.piddock{at}bham.ac.uk


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L. J. V. Piddock and V. Ricci
Accumulation of five fluoroquinolones by Mycobacterium tuberculosis H37Rv
J. Antimicrob. Chemother., December 1, 2001; 48(6): 787 - 791.
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