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Journal of Antimicrobial Chemotherapy (2000) 45, 467-473
© 2000 The British Society for Antimicrobial Chemotherapy

Molecular epidemiology of an outbreak due to IRT-2 ß-lactamase-producing strains of Klebsiella pneumoniae in a geriatric department

Delphine Girlicha, Amal Karima, Laurent Poirela, Marie-Hélène Cavina, Christiane Vernyb and Patrice Nordmanna,*

a Service de Bactériologie-Virologie, b Service de Gériatrie, Hôpital de Bicêtre, 78 rue du Général Leclerc, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre Cedex, France

In February 1998, 195 patients in the geriatric department of a French hospital were screened for the presence of co-amoxiclav-resistant Klebsiella pneumoniae. Eleven co-amoxiclavresistant isolates obtained all produced an identical IRT-2 ß-lactamase. These K. pneumoniae isolates were clonally related and harboured a c. 55 kb non-conjugative plasmid encoding a non-class-1 integron-located blaIRT-2 gene. This study underlines that geriatric departments may be a reservoir for antibiotic-resistant strains and that IRT ß-lactamase-producing strains may be nosocomial pathogens.

* Corresponding author. Tel: +33-1-45-21-36-32; Fax: +33-1-45-21-63-40; E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr


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