Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Strippoli, V.
Right arrow Articles by Simonetti, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Strippoli, V.
Right arrow Articles by Simonetti, N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (2000) 45, 235-237
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Anticandidal activity of SPA-S-843, a new polyenic drug

V. Strippolia, F. D. D'auriab, G. Simonettib, T. Bruzzesea and N. Simonettib,*

Institute of Microbiology, Faculties of a Medicine and Surgery and b Pharmacy, University of Rome ‘La Sapienza’, viale Regina Margherita, 255, 00198 Rome, Italy

The activity of a new, soluble and stable polyene (SPA-S-843) against Candida albicans was assessed by contact and culture tests and by inhibition of germ-tube formation. The drug demonstrated a higher contact activity and lower MICs than amphotericin B. This antimicrobial activity was more evident under acid pH and low ionic strength. In addition, the ability of SPA-S-843 to inhibit Candida sp. conversion from yeast to mycelial form was evident at low drug concentrations (0.25–0.62 mg/L).

* Corresponding author. Tel: +39-6-49914637; Fax: +39-6-49914638.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
G. Mozzi, P. Benelli, T. Bruzzese, M. R. Galmozzi, and A. Bonabello
The use of lipid emulsions for the iv administration of a new water soluble polyene antibiotic, SPK-843
J. Antimicrob. Chemother., February 1, 2002; 49(2): 321 - 325.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.