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Journal of Antimicrobial Chemotherapy (2000) 45, 231-233
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

In vitro activity of ciprofloxacin, sparfloxacin, ofloxacin, amikacin and rifampicin against Ghanaian isolates of Mycobacterium ulcerans

H. S. Thangaraja,*, O. Adjeib, B. W. Allenc, F. Portaelsd, M. R. W. Evansa, D. K. Banerjeec and M. H. Wansbrough-Jonesa

a Division of Infectious Diseases, St George's Hospital Medical School, London SW17 0RE, UK; b Department of Microbiology, School of Medical Sciences, University of Science and Technology, Kumasi, Ghana; c Department of Medical Microbiology, St George's Hospital Medical School, London SW17 0RE, UK; d Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium

MICs of ciprofloxacin, sparfloxacin, ofloxacin, amikacin and rifampicin were determined for 14 primary clinical isolates and three reference isolates of Mycobacterium ulcerans by modifying a standard agar dilution method for testing Mycobacterium tuberculosis sensitivity. All these antimicrobials were active against every isolate of M. ulcerans. Sparfloxacin exhibited the highest activity and ofloxacin was the least effective. Rifampicin exhibited the broadest range of activity.

* Corresponding author. Tel: +44-181-725-5830; Fax: +44-181-725-3487; E-mail: hthangar{at}sghms.ac.uk


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