Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Olsen, K. M.
Right arrow Articles by Rupp, M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Olsen, K. M.
Right arrow Articles by Rupp, M. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (2000) 45, 217-219
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Antimicrobial effects of lidocaine in bronchoalveolar lavage fluid

Keith M. Olsena,*, Tom E. Peddicorda, G. Douglas Campbellb and Mark E. Ruppc

a Department of Pharmacy Practice, University of Nebraska Medical Center, Omaha, NE 68198-6045; b Section of Pulmonary and Critical Care Medicine, Louisiana State University Medical Center, Shreveport, LA 71130; c Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA

The antimicrobial activity of lidocaine in bronchoalveolar lavage fluid (BALf) was investigated. Clinical respiratory isolates were added to BALf suspensions containing lidocaine and to normal saline. The growth of two of four isolates of Streptococcus pneumoniae was significantly reduced in the presence of lidocaine–BALf compared with controls in saline. Growth of Moraxella catarrhalis isolates was reduced in normal saline when compared with BALf containing lidocaine. There was no effect upon the growth of Haemophilus influenzae, Pseudomonas aeruginosa and Candida albicans isolates. The recovery of isolates of S. pneumoniae may be reduced below the critical threshold of 105 cfu/mL during bronchoscopy when using lidocaine as a local anaesthetic.

* Corresponding author. Tel: +1-402-559-9016; Fax: +1-402-559-5673; E-mail: kolsen{at}unmc.edu


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Med MicrobiolHome page
K. Pelz, M. Wiedmann-Al-Ahmad, C. Bogdan, and J.-E. Otten
Analysis of the antimicrobial activity of local anaesthetics used for dental analgesia
J. Med. Microbiol., January 1, 2008; 57(1): 88 - 94.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.