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Journal of Antimicrobial Chemotherapy (2000) 45, 27-29
© 2000 The British Society for Antimicrobial Chemotherapy

In vitro activity of fusidic acid against streptococci isolated from skin and soft tissue infections

R. Leclercqa,b,*, R. Bismuthc, I. Casind, J. D. Cavalloe, J. Croizéf, A. Feltend, F. Goldsteing, H. Monteilh, C. Quentin-Nouryi, M. Reverdyj, M. Vergnaudb and R. Roironk

a Service de Bactériologie-Virologie, Hôpital Henri Mondor-Université Paris XII, 94010 Créteil; b Service de Microbiologie, Hôpital Côte de Nacre, Université de Caen, 14033 Caen; c Service de Bactériologie, Hôpital Pitié-Salpétrière, 74651 Paris cedex 13; d Service de Bactériologie, Hôpital Saint-Louis, 75475 Paris cedex 10; e Service de Biologie, Hôpital Bégin, 94160 Saint-Mandé; f Service de Bactériologie, CHU Grenoble, 38043 Grenoble cedex; g Service de Bactériologie, Hôpital Saint-Joseph, 75674 Paris cedex 14; h Institut de Bactériologie de la Faculté de Médecine, 67000 Strasbourg; i Service de Bactériologie, Hôpital Pellegrin-Tripode, 33076 Bordeaux cedex; j Service de Bactériologie, Hôpital Edouard Herriot, 69437 Lyon cedex 03; k Laboratoires Leo, 78054 Saint-Quentin-en-Yvelines, France

The in vitro activity of fusidic acid was evaluated against 242 strains of streptococci isolated from skin and soft tissue infections during a prospective multicentre study. Nearly 90% of strains were isolated from dermatology, emergency and medicine units. Groups A, B, C and G streptococci represented, respectively, 41.9, 20.6, 4.4 and 27.8% of the strains. The activity of fusidic acid was dependent on the media used. MICs were generally one dilution lower with heart infusion agar than with Mueller–Hinton agar supplemented with 5% horse blood (MIC90 for the whole streptococcal population = 8 mg/L and 16 mg/L, respectively). The distribution of MICs was unimodal and only two strains displayed MICs of fusidic acid >= 64 mg/L. In both media, fusidic acid was moderately active against streptococci. However, antibiotic concentrations obtained in the skin exceed the MIC90 of fusidic acid for streptococci, possibly explaining its clinical efficacy in the treatment of common cutaneous infections.

* Correspondence address. CHU de Caen, Service de Microbiologie, Avenue Côte de Nacre, 14033 Caen cedex, France. Tel: +33-2-31-06-45-72; Fax: +33-2-31-06-45-73; E-mail: leclercq-r{at}chu-caen.fr


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