Journal of Antimicrobial Chemotherapy (2000) 45, 119-121
© 2000 The British Society for Antimicrobial Chemotherapy
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Macrolide resistance in Belgian Streptococcus pneumoniae
Infectious Diseases Research Group, a Departments of Microbiology and Immunology, b Internal Medicine and c Paediatrics, Rega Institute for Medical Research, K.U. Leuven, Belgium
The genetic basis of macrolide resistance was characterized in 59 Streptococcus pneumoniae isolates. All isolates were collected in 1995 and 1997 and were from invasive infections. The majority of the isolates (54 of 59 isolates) were erythromycin and clindamycin resistant (MLSB-phenotype) and carried the ermAM gene. Five isolates were erythromycin resistant but clindamycin susceptible (M-phenotype). Using PCR the mefE gene was detected in these five isolates. Contrary to the situation found in Canada and the USA, mefE-mediated erythromycin resistance in S. pneumoniae is uncommon in Belgium.
1 Correspondence address. Rega Institute, Minderbroedersstraat 10, 3000 Leuven, Belgium. Tel: +32-16-33-73-72; Fax: +32-16-33-73-40; E-mail: katrien.lagrou{at}rega.kuleuven.ac.be
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