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Journal of Antimicrobial Chemotherapy (1999) 44, 854-856
© 1999 The British Society for Antimicrobial Chemotherapy

Correspondence

Safety of metronidazole during pregnancy: a cohort study of risk of congenital abnormalities, preterm delivery and low birth weight in 124 women

J Antimicrob Chemother 1999; 44: 854-855

Henrik Toft Sørensena,b,e,*, Helle Larsenc, Elise Snitker Jensend, Ane Marie Thulstrupa,e, Henrik C. Schønheyderd, Gunnar Lauge Nielsenb, Andrew Czeizelf and the EUROMAP Study Group,{dagger}

aThe Danish Epidemiology Science Centre at the Department of Epidemiology and Social Medicine, University of Aarhus, Vennelyst Boulevard 6, DK-8000 Aarhus C, Denmark bThe Department of Medicine M, Aalborg Hospital, DK-9000 Aalborg, Denmark cThe Department of Gynaecology and Obstetrics, Aalborg Hospital, 9000 Aalborg, Denmark dThe Department of Clinical Microbiology, Aalborg Hospital, DK-9000 Aalborg, Denmark eThe Department of Medicine V, Aarhus University Hospital, DK-8000 Aarhus C, Denmark fFoundation for the Community Control of Hereditary Diseases, Budapest, Hungary

Sir,

Metronidazole is widely used in the treatment of trichomoniasis and bacterial vaginosis in women.1 The agent crosses the placenta throughout gestation. Available data on the safety of the drug during pregnancy are contradictory and valid data on the safety of metronidazole in pregnancy are still needed.2,3 A population-based cohort study in North Jutland County, Denmark was conducted to compare the prevalence of congenital abnormalities, low birth weight and preterm delivery among fetuses exposed to metronidazole (for details regarding methodology see Sørensen et al., 19994). . . . [Full Text of this Article]

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