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Journal of Antimicrobial Chemotherapy (1999) 44, 843-845
© 1999 The British Society for Antimicrobial Chemotherapy

Antimicrobial practice

Assessment of the efficacy, safety and quality of gentamicin use in Aberdeen Royal Infirmary

K. O. Buabenga, A. R. Mackenzieb, R. B. S. Laingb,*, I. Cookc, B. Jappya and I. M. Gouldc

aDepartment of Pharmacy, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZB bThe Infection Unit, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZB cDepartment of Medical Microbiology, University of Aberdeen, UK

Abstract

Fifty-five patients who received od gentamicin were studied. The protocol for od gentamicin was followed in 23/55 (48%). Cure rates were 22/23 (96%) when the protocol was followed and 24/32 (75%) when not followed (P = 0.06). Toxicity was more common in those in whom the protocol was not followed (9/32; 28%) than in those in whom it was followed (1/23; 4%) (P< 0.05). The number needed to treat with the protocol to produce one additional cure was 4.84 (95% CI 2.64 to 28.66) and the number needed to treat to prevent one case of toxicity was 3.61 (95% CI 2.16 to 10.99).

Notes

* Corresponding author. Tel: +44-1224-681818; Fax: +44-1224-849154; E-mail: rbs.laing{at}arh.grampian.scot.nhs.uk


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