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Journal of Antimicrobial Chemotherapy (1999) 44, 689-691
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

In-vitro effects of a combination of antipseudomonal antibiotics against multi-drug resistant Pseudomonas aeruginosa

Shigeharu Oiea, Akihiro Sawaa, Akira Kamiyaa,* and Hidekazu Mizunob

a Department of Pharmacy b Clinical Laboratory, Yamaguchi University Hospital, 1144 Kogushi, Ube 755, Japan

We evaluated the in-vitro effects of various combinations of five types of widely used antipseudomonal antibiotics (piperacillin, meropenem, ceftazidime, aztreonam and amikacin) against six Pseudomonas aeruginosa strains that were resistant to each of these antibiotics. Among two-drug combinations, the combinations of two ß-lactam antibiotics inhibited growth of one to three P. aeruginosa strains, while those of one ß-lactam antibiotic and amikacin inhibited growth of two to four strains. Among three-drug combinations, the combinations of three ß-lactam antibiotics inhibited growth of four to five strains, and those of two ß-lactam antibiotics and amikacin inhibited growth of five strains. These results suggest the potential usefulness of a combination of two ß-lactam antibiotics and amikacin or that of three ß-lactam antibiotics in treating multi-drug resistant P. aeruginosa infections.

* Corresponding author. Tel:+81-836-22-2665; Fax: +81-836-22-2705.


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