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Journal of Antimicrobial Chemotherapy (1999) 44, 578-580
© 1999 The British Society for Antimicrobial Chemotherapy

Correspondence

In-vitro activities of 11 antibiotics against 75 strains of Streptococcus pneumoniae with reduced susceptibilities to penicillin isolated from patients in Washington State

J Antimicrob Chemother 1999; 44: 578–580

Vicki A. Luna and Marilyn C. Roberts*

Department of Pathobiology, Box 357238, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195-7238, USA

Sir,

The incidence of multidrug resistance (i.e. resistance to two or more antibiotic classes) amongst clinical isolates of Streptococcus pneumoniae has increased markedly over the last 10 years;1 most of these strains belong to one of five serogroups (6, 9, 14, 19 and 23). This situation has prompted a search for alternative antibiotics, especially for the treatment of patients with invasive pneumococcal diseases.2 The present study was undertaken to evaluate the in-vitro activities of some of the newer agents . . . [Full Text of this Article]

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