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Journal of Antimicrobial Chemotherapy (1999) 44, 569-572
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Amphotericin B lipid complex at 3 mg/kg/day for treatment of invasive fungal infections in adults with haematological malignancies

Rodrigo Martino*, Maricel Subirá, Anna Sureda and Jorge Sierra

Division of Clinical Haematology, Hospital de la Santa Creu i Sant Pau, Av. Sant Antoni Ma Claret, 167, 08025 Barcelona, Spain

We treated 10 consecutive adults with a haematological malignancy, and an invasive aspergillosis (n = 8) or invasive candidosis (n = 2), with amphotericin B lipid complex (ABLC) at 3 mg/kg/day. Nine patients responded (five complete and four partial responses), and one died with invasive aspergillosis. Treatment was well tolerated, with only 4% of infusions followed by infusion-related adverse events, and the renal function improved in six patients who had an elevated serum creatinine before therapy. These data suggest that lower doses of ABLC may be equally effective but less toxic than higher doses. However, a controlled study is required to confirm these observations.

* Corresponding author. Tel: +34-934-919-396; Fax: +34-932-919-466; E-mail:rmartino{at}hsp.santpau.es


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