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Journal of Antimicrobial Chemotherapy (1999) 44, 565-568
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Intracerebral activity of antibiotics against Listeria monocytogenes during experimental rhombencephalitis

Stéphane Blanot, Claire Boumaila and Patrick Berche*

INSERM U.411, Laboratoire de Microbiologie, Faculté de Médecine Necker-Enfants Malades 156, rue de Vaugirard, 75730 Paris Cedex 15, France

We used a model of rhombencehalitis in gerbils to test the efficacy of various antibiotics against Listeria monocytogenes. Gerbils were inoculated in the middle ear with strain EGD and treated subcutaneously with various antibiotics alone or in combination. We found that the most active antibiotics on intracerebral bacteria were amoxycillin, co-trimoxazole, rifampicin and imipenem. Vancomycin, gentamicin and ciprofloxacin were weakly or not active. The combinations amoxycillin–co-trimoxazole, amoxycillin–gentamicin and co-trimoxazole–rifampicin were highly active against intracerebral bacteria.

* Corresponding author. Tel: +33-1-40-61-53-79; Fax: +33-1-40-61-55-92; E-mail: berche{at}necker.fr


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