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Journal of Antimicrobial Chemotherapy (1999) 44, 561-564
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Modification of acquired immunity in mice by imipenem/cilastatin

Elena Ortegaa, Manuel A. de Pabloa, Aurelia M. Gallegoa, José Juan Gaforioa, Carmen Alvareza, Alfonso Ruiz-Bravob and Gerardo Alvarez de Cienfuegosa,*

a Department of Health Sciences, University of Jaén, 23071-Jaén b Department of Microbiology, University of Granada, 18071-Granada, Spain

The immunomodulating properties of antimicrobial drugs may have important implications for clinical practice, particularly for those patients whose immune system has been compromised. In this study, we assessed the influence of different treatments with a ß-lactam antibiotic (imipenem/cilastatin) on several acquired immune responses of BALB/c mice; splenocyte responses to specific mitogens and to sheep red blood cells, IL-2 production and proportions of the different lympho-monocytic populations. Impenem/cilastatin was shown to modify some lymphocyte-associated immune functions and it would be useful to investigate whether immunomodulatory effects also occur in humans.

* Correspondence address. Department of Health Sciences, Faculty of Experimental Sciences, University of Jaén, Paraje Las Lagunillas s/n, 23071-Jaén, Spain. Tel: +34-9-53-21-21-60; Fax: +34-9-53-21-21-41; E-mail: gcienfue{at}ujaen.es


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