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Journal of Antimicrobial Chemotherapy (1999) 44, 461-464
© 1999 The British Society for Antimicrobial Chemotherapy

Macrolide resistance mechanisms and expression of phenotypes among Streptococcus pneumoniae circulating in Italy

A. Marchese, E. Tonoli, E. A. Debbia and G. C. Schito*

Institute of Microbiology, University of Genoa, Largo R. Benzi 10, 16132 Genoa, Italy

In Italy, macrolide-resistant pneumococci have been isolated at a rate increasing from 6% in 1993 to 31.7% in 1998. A collection of 161 erythromycin-resistant Streptococcus pneumoniae recovered between 1993 and 1997 has now been phenotypically and genotypically characterized. Approximately 90% of these microorganisms possessed a constitutive MLSB mechanism of resistance. PCR detected ermB and mefE genes in strains showing MLSB and M phenotypes, respectively. Using pulsed-field gel electrophoresis of chromosomal DNA, one dominant restriction profile and its variations were detected in 51 S. pneumoniae isolates collected from different locations, indicating the circulation of a clone characterized by the possession of a great ability to spread.

* Corresponding author. Tel: +39-10-353-7655; Fax: +39-10-504-837; E-mail: schitogc{at}aleph.it


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