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Journal of Antimicrobial Chemotherapy (1999) 44, 407-409
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Teicoplanin pharmacokinetics in critically ill paediatric patients

Amelia Sánchez, Jesús López-Herce*, Elisa Cueto, Angel Carrillo and Ramón Moral

Paediatric Intensive Care Section, Gregorio Marañón University General Hospital, Madrid, Spain

Twenty-one critically ill children aged between 7 days and 12 years were treated with teicoplanin (three loading dosages of 10 mg/kg at 12 h intervals, followed by a maintenance dosage of 10 mg/kg/day). Serum teicoplanin concentrations were monitored by HPLC. Mean concentrations in plasma 30 min after drug administration were 20 ± 16.1 mg/L. The volume of distribution was 0.30 L/kg and the terminal half-life was 17.41 h. Only 11% of trough values were >10 mg/L (established as desirable values). In critically ill children a dosage of 10 mg/kg/day does not assure serum trough values >10 mg/L.

* Correspondence address. Arzobispo Morcillo 52 9° C, 28029 Madrid, Spain. Tel: +34-9-1-3145613; Fax: +34-9-1-5868018; E-mail: pielvi{at}mx4.redestb.es


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