Journal of Antimicrobial Chemotherapy (1999) 44, 381-384
© 1999 The British Society for Antimicrobial Chemotherapy
Brief report |
Antipneumococcal activity of MEN 10700, a new penem, compared with other compounds, by MIC and time–kill kinetics
a Department of Pathology (Clinical Microbiology), Hershey Medical Center, 500 University Drive, Hershey, PA 17033 b Case Western Reserve University, Cleveland, OH 44106, USA
The antipneumococcal activity of MEN 10700 was compared with those of nine other compounds by MIC and time–kill kinetics. MIC90s (mg/L) of 202 penicillin-susceptible, -intermediate and -resistant pneumococci were: 0.06, 1.0 and 2.0 (MEN 10700); 0.06, 0.5–1.0 and 2.0 (amoxycillin ± clavulanate); 0.06, 0.5 and 4.0 (cefotaxime); 0.125, 0.5 and 2.0 (cefepime); 0.016, 0.125 and 0.25 (imipenem); 0.03, 0.5 and 1.0 (meropenem); 2.0 (ciprofloxacin); 0.125, > 64.0 and > 64.0 (clarithromycin); and 0.5 (vancomycin). Time–kill kinetics showed that MEN 10700, at 4 x MIC, was bactericidal for all 12 isolates tested at 4 x MIC. Kinetics of other ß-lactams were similar to those of MEN 10700, relative to MICs. Ciprofloxacin, at 4 x MIC, was uniformly bactericidal after 24 h. Clarithromycin exhibited slow kill kinetics, after 24 h. Vancomycin was bactericidal against 11/12 isolates at 2 x MIC after 24 h.
* Corresponding author. Tel: +1-717-531-5113; Fax: +1-717-531-7953; E-mail: pappelbaum{at}psghs.edu