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Journal of Antimicrobial Chemotherapy (1999) 44, 297-298
© 1999 The British Society for Antimicrobial Chemotherapy

Correspondence

In-vitro activity of polyhexamethylene biguanide (PHMB) against fungal isolates associated with infective keratitis

J Antimicrob Chemother 1999; 44: 297–298

Chad R. Messicka, Susan L. Pendlandb,c,*, Majid Moshirfard, Richard G. Fiscellac,e, Karen J. Losnedahlb,c, Christopher A. Schrieverb,c and Paul C. Schreckenbergerf

a Veterans Affairs Cooperative Studies Program, Clinical Research Pharmacy Coordinating Center, Albuquerque, NM b Microbiology Research Laboratory c Department of Pharmacy Practice e Department of Ophthalmology f Department of Pathology, University of Illinois at Chicago, Chicago, IL d John A. Moran Eye Center, Salt Lake City, UT, USA

Sir,

Fungal keratitis is an infection that is difficult both to diagnose and to treat. Candida albicans, other yeasts and the septate moulds, Fusariumspp. and Aspergillus spp., are common causes of this disease. Treatment options are limited and include topical formulations of natamycin (5%), amphotericin B (0.15%) and fluconazole (1%). However, the efficacies of these agents are compromised by poor ocular penetration, poor tolerability and/or poor in-vitro activity. 1 Polyhexamethylene biguanide (PHMB), which is currently used as an environmental biocide and contact lens . . . [Full Text of this Article]

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M. J. Allen, G. F. White, and A. P. Morby
The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide.
Microbiology, April 1, 2006; 152(Pt 4): 989 - 1000.
[Abstract] [Full Text] [PDF]