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Journal of Antimicrobial Chemotherapy (1999) 44, 291-293
© 1999 The British Society for Antimicrobial Chemotherapy

Correspondence

Setting the standard for determining the in-vitro susceptibility of Helicobacter pylori to metronidazole

J Antimicrob Chemother 1999; 44: 291–293

Tanittha Chatsuwan* and Sebastian G. B. Amyes

Department of Medical Microbiology, The Medical School, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK

Sir,

Metronidazole is frequently included in regimens used to eradicate Helicobacter pylori. However, the rates of metronidazole resistance amongst H. pylori isolates are highly variable—from 11% to 70% in developed countries and even higher in developing countries. 1 As susceptibility testing of H. pylorihas not been standardized, it may be that variations in the rates of resistance can be accounted for by differences in the methods of determining susceptibility. For example, Smith & Edwards 2 demonstrated that H. pylori NCTC 11637 is resistant to metronidazole when tested under microaerophilic growth conditions, but susceptible when tested under anaerobic . . . [Full Text of this Article]

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