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Journal of Antimicrobial Chemotherapy (1999) 44, 283-286
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

In-vitro comparative activity of UR-9825, itraconazole and fluconazole against clinical isolates of Candida spp.

Gema Ramos, Manuel Cuenca-Estrella, Araceli Monzón and Juan L. Rodríguez-Tudela*

Unidad de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain

UR-9825 is a new broad-spectrum triazole antifungal agent with a good pharmacokinetic profile and excellent bioavailability. It shows high in-vitro activity and efficacy in models of systemic candidosis in rats and rabbits, comparing favourably with fluconazole. The purpose of this study was to evaluate the in-vitro activity of UR-9825 and to compare it with that of fluconazole and itraconazole against 283 clinical isolates of Candida spp. UR-9825 was more potent against Candida spp. than both fluconazole and itraconazole, even against some Candida albicans and Candida krusei isolates with decreased susceptibility to fluconazole (MIC 16 mg/L).

* Corresponding author: Tel: +34-91-5097961; Fax: 34-91-5097966


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