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Journal of Antimicrobial Chemotherapy (1999) 44, 135
© 1999 The British Society for Antimicrobial Chemotherapy

Correspondence

Carbapenem-hydrolysing ß-lactamase from clinical isolates of Pseudomonas aeruginosa in Portugal

J Antimicrob Chemother 1999; 44: 135

Olga Cardosoaa,*, João Carlos Sousab, Rui Leitãoa and Luísa Peixeb

a Laboratório de Microbiologia da Faculdade de Farmácia da Universidade de Coimbra, Couraça dos Apostolos 51 r/c 3030 Coimbra b Laboratório de Microbiologia da Faculdade de Farmácia do Porto, Rua Aníbal Cunha 164 4050-Porto, Portugal

Sir,

Although the carbapenem antibiotics have the broadest antibacterial activity of all ß-lactams, strains of Pseudomonas aeruginosa resistant to these agents have been reported. The mechanisms of the acquired imipenem resistance in this species may result from a decrease in the uptake of carbapenems and from an increased expression of the pump efflux. In . . . [Full Text of this Article]

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