Journal of Antimicrobial Chemotherapy (1999) 43, 783-792
© 1999 The British Society for Antimicrobial Chemotherapy
Prevalence of resistance to MLS antibiotics in 20 European university hospitals participating in the European SENTRY surveillance programme
Eijkman- Winkler Institute for Clinical Microbiology, Utrecht University, Utrecht, The Netherlands
Macrolide, lincosamide and streptogramin (MLS) antibiotics are chemically distinct inhibitors of bacterial protein synthesis. Resistance to MLS antibiotics may be constitutive or inducible. The purpose of this study is to update our understanding of the prevalence of different forms of MLS resistance in Europe. The analysis of 3653 clinical pneumococcal, staphylococcal and enterococcal isolates exhibited an average percentage of 21.3% and 6.2% intermediate and high-level penicillin-resistant Streptococcus pneumoniae, 21.8% methicillin-resistant Staphylococcus aureus and 11% vancomycin-resistant Enterococcus faecium. Geographical differences in erythromycin and clindamycin resistance in isolates of S. pneumoniae and S. aureus strongly reflect geographical variations in susceptibility to penicillin and methicillin, respectively. A very narrow range of MICs was obtained with quinupristin/dalfopristin, with no S. pneumoniae, S. aureus and E. faecium isolate having an MIC of >4 mg/L, indicating a possible role of quinupristin/dalfopristin in the treatment of infections by multi-resistant Gram-positive bacteria.
* Correspondence address. Institute for Medical Microbiology and Virology, Henrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb. 22.21, 40225 Düsseldorf, Germany. Tel and Fax: +49-2132-72040.
The SENTRY participants group consists of: Professor Helmut
Mittermayer, Professor Marc Struelens, Professor Jacques Acar, Professor Vincent Jarlier,
Professor Jerome Etienne, Professor Rene Courcol, Professor Franz Daschner, Professor Ulrich
Hadding, Professor Nikos Legakis, Professor Gian-Carlo Schito, Professor Carlo Mancini,
Professor Piotr Heczko, Professor Waleria Hyrniewicz, Professor Dario Costa, Professor Evilio
Perea, Professor Fernando Baquero, Dr Rogelio Martin Alvarez, Professor Jacques Bille and
Professor Gary French.
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