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Journal of Antimicrobial Chemotherapy (1999) 43, 608-610
© 1999 The British Society for Antimicrobial Chemotherapy

Correspondence

Outer membrane permeability of the antibiotic-supersusceptible lipid A mutants of Escherichia coli to hydrophobic steroid probes

J Antimicrob Chemother 1999; 43: 608–610

Patrick Plésiata and Martti Vaarab,c,*

a Laboratoire de Bactériologie, Faculté de Médecine, Besançon, France b Department of Bacteriology and Immunology, University of Helsinki c Department of Bacteriology, National Public Health Institute, Helsinki, Finland

Sir,

Many clinically important Gram-negative bacteria possess effective outer membrane (OM) permeability barriers that markedly limit the penetration and, thus, the activities of hydrophobicantibiotics, such as erythromycin and rifampicin, and large antibiotic molecules, such asvancomycin. 1,2 This, in part, explains why these pathogens are resistant to most of the recently discoveredagents (e.g. the oxazolidinones and everninomicin) that exhibit potent activities against Gram-positive bacteria. 3 The barrier function of the OM relies principally on the compact leaflet of lipopolysaccharide (LPS) molecules that covers the cell surface and which is fairly impermeable to hydrophilic and (moderately) hydrophobic compounds. This is exemplified by . . . [Full Text of this Article]

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