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Journal of Antimicrobial Chemotherapy (1999) 43, 593-596
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Concentration and bactericidal activity of fusidic acid and cloxacillin in serum and synovial fluid

E. Somekha,*, T. Golana, A. Tanayb, F. Pochc and M. Danc

a Pediatric Infectious Diseases Unit, E. Wolfson Medical Center, Holon, Israel b Clinical Immunology Unit, E. Wolfson Medical Center, Holon, Israel c Infectious Diseases Unit, E. Wolfson Medical Center, Holon, Israel

Fusidic acid and cloxacillin were studied in patients who underwent joint aspiration for non-infectious disorders. Nine patients were given oral 500 mg fusidic acid tid for 72 h, the last dose being given 4, 8 or 12 h before the joint aspiration. Cloxacillin was administered in a single 2 g iv dose to 9 patients, 0.5, 4 or 8 h before the aspiration. Bactericidal activity was determined against five isolates each of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. Satisfactory activity (>=1:3) was detected in the serum in patients who received fusidic acid, while in the synovial fluids titres reflected borderline effectiveness (c.1:2). Despite drug concentrations and excellent MICs, fusidic acid demonstrated markedly lower inhibitory and bactericidal activity against S. aureus than did cloxacillin.

* The Pediatric Infectious Diseases Unit, E. Wolfson Medical Center, Holon 58100, Israel. Tel: +972-3-5028278; Fax: +972-3-5036408.


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