Journal of Antimicrobial Chemotherapy (1999) 43, 559-562
© 1999 The British Society for Antimicrobial Chemotherapy
Brief report |
Inducible or constitutive expression of resistance in clinical isolates of streptococci and enterococci cross-resistant to erythromycin and lincomycin
a Service de Bactériologie-Virologie, Hôpital Henri Mondor-Université Paris XII, 94010 Créteil b Service de Microbiologie, Hôpital Côte de Nacre, Université de Caen, 14033 Caen, France
Thirty-five of 40 clinical isolates of enterococci and streptococci cross-resistant to erythromycin and lincomycin and harbouring erm genes were inducibly resistant to these drugs, suggesting that ribosomal methylation is predominantly inducibly expressed in these bacterial genera. Regulatory regions located upstream of the erm genes of four inducible and three constitutive strains were amplified and sequenced. Expression of constitutive resistance in two strains of Streptococcus pneumoniae and Enterococcus faecalis could be accounted for by a large deletion or a DNA duplication within the regulatory regions, respectively.
* Corresponding author. CHU de Caen, Service de Microbiologie, Avenue Côte de Nacre, 14033 Caen cedex, France. Tel: +33-2-31-06-45-72; Fax: +33-2-31-06-45-73; E-mail: leclercq-r{at}chu-caen.fr
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