Journal of Antimicrobial Chemotherapy (1999) 43, 447-458
© 1999 The British Society for Antimicrobial Chemotherapy
Review |
Inhibitor-resistant TEM ß-lactamases: phenotypic, genetic and biochemical characteristics
a UMR 175, CNRS-MNHN, 6 Rue de l'Université, 29000 Quimper b Laboratoire de Bactériologie, Faculté de Médecine, 28 Place Henri-Dunant, 63001 Clermont-Ferrand Cedex c CHU Cochin, Laboratoire de Bactériologie, 75014 Paris, France
ß-Lactamases represent the main mechanism of bacterial resistance to ß-lactam antibiotics. The recent emergence of bacterial strains producing inhibitor-resistant TEM (IRT) enzymes could be related to the frequent use of ß-lactamase inhibitors such as clavulanic acid, sulbactam and tazobactam in hospitals and in general practice. The IRT ß-lactamases differ from the parental enzymes TEM-1 or TEM-2 by one, two or three amino acid substitutions at different locations. This paper reviews the phenotypic, genetic and biochemical characteristics of IRT ß-lactamases in an attempt to shed light on the pressures that have contributed to their emergence.
* Corresponding author. Tel: +33-2-98908035; Fax: +33-2-98908048; E-mail: roger.labia{at}univ-brest.fr
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