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Journal of Antimicrobial Chemotherapy (1999) 43, 411-413
© 1999 The British Society for Antimicrobial Chemotherapy

Brief reports

Comparisons of the effects of fungicidal and fungistatic antifungal agents on the morphogenetic transformation of Candida albicans

Stephen Hawser* and Khalid Islam

Hoechst Marion Roussel, 102 Route de Noisy, 93235 Romainville Cedex, France

Eleven different antifungal agents were compared, and their ability to inhibit the morphogenetic transformation of Candida albicans was examined together with their ability to inhibit growth, as measured by MIC methodology. The fungicidal potential of each agent was also determined. Of the antifungal agents tested, only amphotericin B, mulundocandin and aculeacin inhibited the transformation at sub-MIC values; all three agents showed fungicidal activity at concentrations close to the MIC. All other agents were fungicidal only at concentrations much higher than the MIC and inhibited the morphogenetic transformation only at concentrations above the MIC. These data suggest that fungicidal antifungal agents are more likely to act by inhibiting the morphogenetic transformation of C. albicans while fungistatic agents are unable to do so and are more likely to block growth by budding.

* Tel: +33-1-49913097; Fax: +33-1-4991-5061; E-mail: Stephen.hawser{at}hmrag.com


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 Antimicrob. Agents Chemother.Home page
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