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Journal of Antimicrobial Chemotherapy (1999) 43, 313
© 1999 The British Society for Antimicrobial Chemotherapy


Correspondence

The influence of factors affecting the `critical population' density of inocula on the determination of bacterial susceptibility to antibiotics by disc diffusion methods

J Antimicrob Chemother 1999; 43: 313

Alan J. Hedges

Department of Pathology and Microbiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK

Sir,

The recent article by Gosden et al. 1 prompted me to reflect on the widespread use of disc diffusion methods for determining antibiotic susceptibility that ignore an important finding of the definitive studies of Cooper 2 and Linton 3 on the formation of inhibition zones. These investigators showed . . . [Full Text of this Article]

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