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Journal of Antimicrobial Chemotherapy (1999) 43, 295-299
© 1999 The British Society for Antimicrobial Chemotherapy

Brief reports

In-vitro activity of five antifungal agents against uncommon clinical isolates of Candida spp.

Francesco Barchiesia,*, Anna Maria Tortoranob, Luigi Falconi Di Francescoa, Massimo Cogliatib, Giorgio Scalisea and Maria Anna Vivianib

a Istituto di Malattie Infettive e Medicina Pubblica, Università degli Studi di Ancona; b Istituto di Igiene e Medicina Preventiva, Università degli Studi di Milano, IRCCS Ospedale Maggiore di Milano, Italy

A broth microdilution method and an agar dilution method were used for testing fluconazole, itraconazole, ketoconazole, flucytosine and amphotericin B against 98 clinical isolates belonging to seven species of Candida. The approximate rank order of fluconazole MICs was Candida lusitaniae {approx} Candida kefyr< Candida famata{approx}Candida guilliermondii< Candida pelliculosa {approx} C. lipolytica {approx} Candida inconspicua. Candida lypoliticaand C. pelliculosa were the species least susceptible to itraconazole and ketoconazole. Flucytosine MICs revealed the highest prevalence of resistant strains among C. lipolyticaand C. lusitaniae. All isolates were susceptible to amphotericin B.

* Correspondence address. Istituto di Malattie Infettive e Medicina Pubblica, Università degli Studi di Ancona, Ospedale Umberto I, Largo Cappelli 1, 60121 Ancona, Italy. Tel: +39-71-5963467; Fax: +39-71-5963468; E-mail: cmalinf{at}popcsi.unian.it


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