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Journal of Antimicrobial Chemotherapy (1999) 43, 291-294
© 1999 The British Society for Antimicrobial Chemotherapy

Brief reports

In-vitro bactericidal activity of cefpirome and cefamandole in combination with glycopeptides against methicillin-resistant Staphylococcus aureus

M. Bergeret and J. Raymond*

Service Microbiologie, Hüpital Saint Vincent de Paul, 82, avenue Denfert Rochereau, 75674 Paris Cedex 14, France

The bactericidal activity in vitro of cefpirome plus either vancomycin or teicoplanin was compared with that of a cefamandole–vancomycin combination against ten clinical isolates of homogeneous methicillin-resistant Staphylococcus aureus. Cefpirome (0.125 x MIC) combined with vancomycin (0.5–2x MIC) or teicoplanin (0.5–4x MIC) acted synergically against the ten isolates. Similar effects were observed with the cefamandole–vancomycin combination, except that for one isolate, higher cefamandole concentrations (0.25–1x MIC) were required.

* Corresponding author. Tel:+33-1-40-48-82-42; Fax: +33-1-40-48-83-18; E-mail: j.raymond{at}svp.ap-hop-paris.fr


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