Journal of Antimicrobial Chemotherapy (1999) 43, 277-279
© 1999 The British Society for Antimicrobial Chemotherapy
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Relationship between haemolysis production and resistance to fluoroquinolones among clinical isolates of Escherichia coli
a Department of Microbiology, University Hospital Virgen Macarena; b School of Medicine, Seville, Spain
The activities of ampicillin, amoxycillin-clavulanic acid, gentamicin, tetracycline, nalidixic acid, ciprofloxacin, pefloxacin and trovafloxacin against 207 consecutive clinical isolates of Escherichia coli were determined. Fifty-six (27.3%) isolates were haemolytic. The percentages of resistance to quinolones and tetracycline, but not to other agents, among haemolytic isolates were significantly lower (P < 0.05) than among non-haemolytic isolates. Ciprofloxacin-resistant mutants obtained from ciprofloxacin-susceptible haemolytic isolates still produced haemolysis. It is concluded that most quinolone-resistant clinical isolates of E. coli are non-haemolytic, although haemolysis is produced by quinolone-resistant mutants derived from haemolytic quinolone-susceptible strains.
* Correspondence address. Department of Microbiology, School of Medicine, Apdo 914, 41080 Seville, Spain. Tel: +34-95-4557448; Fax:+34-95-4377413; E-mail: lmartin{at}cica.es
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