Journal of Antimicrobial Chemotherapy (1999) 43, 164-165
© 1999 The British Society for Antimicrobial Chemotherapy
Correspondence |
General stress response master regulator rpoS is expressed in human infection: a possible role in chronicity
J Antimicrob Chemother 1999; 43: 164- 165
a Department of Biological Sciences, University of Warwick, Coventry CV4 7PL; b Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY; c Pharmaceutical Sciences Institute, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
Sir,
Recently, there has been much interest in an aspect of the stationary phase of non-sporulating
environmental bacteria termed the general stress response (GSR), which results in cells resistant
to numerous physical and chemical stresses.
1 The final, non-replicating stages have been variously
described as quiescent, resting, or dormant. We wished to test the hypothesis that this response to
stress could be a critical event in chronic infection, resulting in
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