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Journal of Antimicrobial Chemotherapy (1999) 43, 158-160
© 1999 The British Society for Antimicrobial Chemotherapy

Correspondence

Adherent bacteria and activity of antibiotics

J Antimicrob Chemother 1999; 43: 158–160

J. M. Schierholz, J. Beuth and G. Pulverer

Institute for Medical Microbiology and Hygiene, University of Cologne, Goldenfelsstrasse 19- 21, 50935 Cologne, Germany

Tel: +49-221-478-3060; Fax: +49-221-478-3067.

Sir,

We read with interest the recent correspondence in the journal from Gilbert & Brown, 1 in which they comment on the activity of antibiotics in biofilms.

In general, the dominant mechanisms of biofilm resistance may be related to the suppression of bacterial growth within the biofilm, to physicochemical interaction of the glycocalyx with certain antibiotics (via dipole- dipole-, H-, and ionic-bonds, . . . [Full Text of this Article]

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