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Journal of Antimicrobial Chemotherapy (1999) 43, 153-155
© 1999 The British Society for Antimicrobial Chemotherapy

Brief reports

The concentrations of clinafloxacin in alveolar macrophages, epithelial lining fluid, bronchial mucosa and serum after administration of single 200 mg oral doses to patients undergoing fibre-optic bronchoscopy

D. Honeybourneb, J. M. Andrewsa, B. Cunninghamb, G. Jevonsa and R. Wisea

a Department of Medical Microbiology, City Hospital NHS Trust, Birmingham, UK b Department of Thoracic Medicine, City Hospital NHS Trust, Birmingham, UK

Abstract

The concentrations of clinafloxacin were measured in serum, bronchial mucosa, alveolar macrophages and epithelial lining fluid after single 200 mg oral doses of clinafloxacin had been administered to 15 subjects who were undergoing bronchoscopy. Concentrations were measured using a microbiological assay method. Mean concentrations in serum, bronchial mucosa, alveolar macrophages and epithelial lining fluid at a mean of 1.27 h post-dose were 1.54, 2.65, 15.60 and 2.71 mg/L respectively. These site concentrations exceeded the MIC90 for common respiratory pathogens and indicate that clinafloxacin is likely to be effective in the treatment of a wide range of respiratory tract infections.


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