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Journal of Antimicrobial Chemotherapy, Vol 42, 661-663, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

Absence of a post-antibiotic effect (PAE) of beta-lactams against Helicobacter pylori NCTC 11637

IJ Hassan, RM Stark, J Greenman and MR Millar
Pathology and Microbiology Department, University of Bristol, UK. I.J.Hassan@bristol.ac.uk

A continuous culture system (chemostat) was used to study the post- antibiotic effect (PAE) of beta-lactams, against slowly-growing Helicobacter pylori NCTC 11637. H. pylori was grown at one quarter of its maximum specific growth rate (mu(max)) before exposure to ampicillin, amoxycillin, azlocillin, piperacillin or cefixime (8 x MIC). After 8 h, the antibiotics were inactivated. Viable counts were used to determine the rate of recovery of H. pylori. The recovery growth rate of H. pylori was similar to the maximum growth rate of H. pylori under antibiotic-free experimental conditions, so none of the beta-lactams studied showed a PAE against slowly-growing H. pylori.
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