Journal of Antimicrobial Chemotherapy, Vol 42, 5-12, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
I Phillips
Although the qualitative aspects of antibiotic resistance are increasingly
well understood, our understanding of the quantitative aspects has always
lagged. Deficiency of understanding or of investigation affects the methods
used to characterize the phenotypes of organisms from clinical sources,
delays acquisition of knowledge of the importance of quantitative diversity
in patient management, and introduces error into epidemiological studies of
the prevalence of resistance. This, in turn, gives rise to a devaluation of
the work done in diagnostic laboratories in relation to the technology of
sensitivity testing, to the interpretation of their results for clinicians,
including those used in clinical trials, and to the statistical analyses of
resistance trends used inter alia as a guide to empirical antibiotic
therapy and to test the efficacy of methods of control. There is a need to
bring about a shift of opinion of those who provide funds, in relation to
the role of clinical microbiologists and infectious diseases clinicians in
defining and solving these problems.
ORIGINAL ARTICLES
The 1997 Garrod Lecture. The subtleties of antibiotic resistance
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