Journal of Antimicrobial Chemotherapy, Vol 42, 13-28, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
M Wainwright
Whereas the photodynamic therapy (PDT) of cancer has recently shown rapid
clinical acceptance, photodynamic antimicrobial chemotherapy (PACT)--which
predates the related cancer regimen--is not widely appreciated. Like PDT,
PACT utilizes photosensitizers and visible or ultraviolet light in order to
give a phototoxic response, normally via oxidative damage. Currently, the
major use of PACT is in the disinfection of blood products, particularly
for viral inactivation, although more clinically-based protocols are being
developed, e.g. in the treatment of oral infection. The technique has been
shown to be effective in vitro against bacteria (including drug-resistant
strains), yeasts, viruses and parasites. A wide range of photosensitizers,
both natural and synthetic, is available with differing physicochemical
make- up and light-absorption properties. PACT is proposed as a potential,
low-cost approach to the treatment of locally occurring infection.
REVIEWS
Photodynamic antimicrobial chemotherapy (PACT)
Department of Chemistry, University of Central Lancashire, Preston, UK. M.Wainwright@UCLAN.ac.uk
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Wu, H. Xu, W. Tang, R. Kopelman, M. A. Philbert, and C. Xi Eradication of Bacteria in Suspension and Biofilms Using Methylene Blue-Loaded Dynamic Nanoplatforms Antimicrob. Agents Chemother., July 1, 2009; 53(7): 3042 - 3048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Maclean, S. J. MacGregor, J. G. Anderson, and G. Woolsey Inactivation of Bacterial Pathogens following Exposure to Light from a 405-Nanometer Light-Emitting Diode Array Appl. Envir. Microbiol., April 1, 2009; 75(7): 1932 - 1937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Giladi, Y. Porat, A. Blatt, Y. Wasserman, E. D. Kirson, E. Dekel, and Y. Palti Microbial Growth Inhibition by Alternating Electric Fields Antimicrob. Agents Chemother., October 1, 2008; 52(10): 3517 - 3522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z Chen, S Xuguang, W Zhiqun, and L Ran In vitro amoebacidal activity of photodynamic therapy on Acanthamoeba Br J Ophthalmol, September 1, 2008; 92(9): 1283 - 1286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sharma, L. Visai, F. Bragheri, I. Cristiani, P. K. Gupta, and P. Speziale Toluidine Blue-Mediated Photodynamic Effects on Staphylococcal Biofilms Antimicrob. Agents Chemother., January 1, 2008; 52(1): 299 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. J. Kim and Y. C. Kim Successful Treatment of Pityriasis Versicolor With 5-Aminolevulinic Acid Photodynamic Therapy Arch Dermatol, September 1, 2007; 143(9): 1218 - 1220. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Konopka and T. Goslinski Photodynamic Therapy in Dentistry Journal of Dental Research, August 1, 2007; 86(8): 694 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Fuchs, G. P. Tegos, M. R. Hamblin, and E. Mylonakis Susceptibility of Cryptococcus neoformans to Photodynamic Inactivation Is Associated with Cell Wall Integrity Antimicrob. Agents Chemother., August 1, 2007; 51(8): 2929 - 2936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Metcalf, C. Robinson, D. Devine, and S. Wood Enhancement of erythrosine-mediated photodynamic therapy of Streptococcus mutans biofilms by light fractionation J. Antimicrob. Chemother., July 1, 2006; 58(1): 190 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. P. Tegos, M. Anbe, C. Yang, T. N. Demidova, M. Satti, P. Mroz, S. Janjua, F. Gad, and M. R. Hamblin Protease-Stable Polycationic Photosensitizer Conjugates between Polyethyleneimine and Chlorin(e6) for Broad-Spectrum Antimicrobial Photoinactivation. Antimicrob. Agents Chemother., April 1, 2006; 50(4): 1402 - 1410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wood, D. Metcalf, D. Devine, and C. Robinson Erythrosine is a potential photosensitizer for the photodynamic therapy of oral plaque biofilms J. Antimicrob. Chemother., April 1, 2006; 57(4): 680 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. N. Demidova and M. R. Hamblin Photodynamic Inactivation of Bacillus Spores, Mediated by Phenothiazinium Dyes Appl. Envir. Microbiol., November 1, 2005; 71(11): 6918 - 6925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Embleton, S. P. Nair, W. Heywood, D. C. Menon, B. D. Cookson, and M. Wilson Development of a Novel Targeting System for Lethal Photosensitization of Antibiotic-Resistant Strains of Staphylococcus aureus Antimicrob. Agents Chemother., September 1, 2005; 49(9): 3690 - 3696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Maisch, C. Bosl, R.-M. Szeimies, N. Lehn, and C. Abels Photodynamic Effects of Novel XF Porphyrin Derivatives on Prokaryotic and Eukaryotic Cells Antimicrob. Agents Chemother., April 1, 2005; 49(4): 1542 - 1552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-W. Wong, Y.-Y. Wang, H.-M. Sheu, and Y.-C. Chuang Bactericidal Effects of Toluidine Blue-Mediated Photodynamic Action on Vibrio vulnificus Antimicrob. Agents Chemother., March 1, 2005; 49(3): 895 - 902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gad, T. Zahra, T. Hasan, and M. R. Hamblin Effects of Growth Phase and Extracellular Slime on Photodynamic Inactivation of Gram-Positive Pathogenic Bacteria Antimicrob. Agents Chemother., June 1, 2004; 48(6): 2173 - 2178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Romanova, L. Y. Brovko, L. Moore, E. Pometun, A. P. Savitsky, N. N. Ugarova, and M. W. Griffiths Assessment of Photodynamic Destruction of Escherichia coli O157:H7 and Listeria monocytogenes by Using ATP Bioluminescence Appl. Envir. Microbiol., November 1, 2003; 69(11): 6393 - 6398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Komerik, H. Nakanishi, A. J. MacRobert, B. Henderson, P. Speight, and M. Wilson In Vivo Killing of Porphyromonas gingivalis by Toluidine Blue-Mediated Photosensitization in an Animal Model Antimicrob. Agents Chemother., March 1, 2003; 47(3): 932 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Embleton, S. P. Nair, B. D. Cookson, and M. Wilson Selective lethal photosensitization of methicillin-resistant Staphylococcus aureus using an IgG-tin (IV) chlorin e6 conjugate J. Antimicrob. Chemother., December 1, 2002; 50(6): 857 - 864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Rovaldi, A. Pievsky, N. A. Sole, P. M. Friden, D. M. Rothstein, and P. Spacciapoli Photoactive Porphyrin Derivative with Broad-Spectrum Activity against Oral Pathogens In Vitro Antimicrob. Agents Chemother., December 1, 2000; 44(12): 3364 - 3367. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Wise Science, medicine, and the future: The development of new antimicrobial agents BMJ, September 5, 1998; 317(7159): 643 - 644. [Full Text]
|
|