Journal of Antimicrobial Chemotherapy, Vol 39, 817-820, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
E Svensson, H Hanberger, M Nilsson and LE Nilsson
Selection and regrowth of variants resistant to 0.016-32 mg/L of
rifampicin, which were present at a frequency of 10(-7) in the initial
inoculum, were seen when large inocula (> 10(5) cfu/mL) of
Staphylococcus epidermidis ATCC 35984 were incubated with the drug.
Conventional MIC determinations using approximately 10(5) cfu/mL did not
detect the resistant variants. Larger inocula increased the MIC by >
8000-fold. Population analysis showed that rifampicin concentrations above
the MIC (measured at an inoculum of approximately 10(5) cfu/mL) select
highly resistant variants (MIC > 256 mg/L) when large inocula (> or =
10(5) cfu/mL) were incubated with rifampicin. The resistant variants were
stable through ten passages. It was not possible to prevent regrowth of the
resistant variants by increasing the rifampicin concentration further. At
subinhibitory concentrations there was no development of rifampicin
resistance.
JOURNAL ARTICLE
Factors affecting development of rifampicin resistance in biofilm- producing Staphylococcus epidermidis
Department of Clinical Microbiology, Faculty of Health Sciences, University Hospital, Linkoping, Sweden.
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