Journal of Antimicrobial Chemotherapy, Vol 39, 719-723, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
J George and I Morrissey
The bactericidal activity of levofloxacin was compared with that of four
other quinolones and one cephalosporin against four strains of
Streptococcus pneumoniae with varying degrees of penicillin G
susceptibility. Levofloxacin was found to be the most bactericidal
quinolone at its optimum bactericidal concentration, followed by ofloxacin,
ciprofloxacin, sparfloxacin and D-ofloxacin, in that order. There was no
correlation between quinolone-susceptibility and penicillin-susceptibility
with any quinolone tested. To allow a comparison between the bactericidal
activity of the quinolones and cefotaxime to be made a bactericidal index
was used. Against two penicillin-sensitive pneumococci and a
penicillin-intermediate pneumococcus, cefotaxime was the most potent
antibacterial agent tested, followed by levofloxacin. However, against the
penicillin- resistant pneumococcus, levofloxacin was considerably more
potent than cefotaxime. The remaining quinolones tested were inferior to
levofloxacin. Levofloxacin has enhanced activity against pneumococci
compared with clinically available quinolones. In addition, levofloxacin
may be the future quinolone of choice in the treatment of
penicillin-resistant pneumococci.
JOURNAL ARTICLE
The bactericidal activity of levofloxacin compared with ofloxacin, D- ofloxacin, ciprofloxacin, sparfloxacin and cefotaxime against Streptococcus pneumoniae
Chemotherapy Research Unit, University of East London, UK.
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