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Journal of Antimicrobial Chemotherapy, Vol 39, 643-646, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

JOURNAL ARTICLE

Influence of N-acetylcysteine on the formation of biofilm by Staphylococcus epidermidis

C Perez-Giraldo, A Rodriguez-Benito, FJ Moran, C Hurtado, MT Blanco and AC Gomez- Garcia
Department of Microbiology, Faculty of Medicine, Extremadura University, Badajoz, Spain.

The influence of various concentrations (0.003-8 mg/mL) of N- acetylcysteine on the formation of biofilms by 15 strains of Staphylococcus epidermidis has been studied. A dose-related decrease in biofilm formation was observed, except with the lowest concentrations. The 'slime' index relative to the control was 63%, 55%, 46%, 34%, 26% and 26% in the presence of 0.25, 0.5, 1, 2, 4, and 8 mg/mL of N- acetylcysteine, respectively. These data are statistically significant. The inhibitory effect of 2 mg/mL of N-acetylcysteine on slime formation was also verified by electron microscopy.
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