Journal of Antimicrobial Chemotherapy, Vol 39, 617-622, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
SL Nielsen, N Obel, M Storgaard and PL Andersen
The effect of ciprofloxacin, lomefloxacin, fleroxacin and ofloxacin on the
intracellular killing of Staphylococcus aureus in human neutrophil
granulocytes was studied. Each drug was tested in concentrations of 0.25,
1, 4, 16 and 64 times the MIC and the intracellular killing was measured
for up to 5 h of incubation. All four quinolones increased the
intracellular killing in a concentration- and time-dependent manner. When
compared at concentrations of 4 x MIC, ofloxacin increased the killing
significantly more than the other quinolones. All four quinolones increased
the killing significantly more than the beta- lactam dicloxacillin. All
five antibiotics increased the killing significantly relative to the
control without antibiotics. None of the antibiotics affected the viability
of the granulocytes or their ability to generate superoxide anion. In
conclusion, the quinolones increased the intracellular killing of S. aureus
in neutrophil granulocytes.
JOURNAL ARTICLE
The effect of quinolones on the intracellular killing of Staphylococcus aureus in neutrophil granulocytes [published erratum appears in J Antimicrob Chemother 1997 Sep;40(3):462]
Department of Medicine and Infectious Diseases, Marselisborg Hospital, Aarhus University Hospital, Denmark.
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