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Journal of Antimicrobial Chemotherapy, Vol 39, 269-271, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

JOURNAL ARTICLE

Lack of chondrotoxicity of ofloxacin otic solution on the auditory ossicle cartilages of juvenile guinea pigs

M Kato, K Akahane and K Shimoda
Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd, Edogawa, Tokyo, Japan.

The effect of 0.3% otic solution of ofloxacin on the cartilages constituting the epiphyses of the auditory ossicles and the wall of the auditory tube was histologically examined after 30-day repeated intratympanic administration to juvenile male guinea pigs aged 4 weeks. Ofloxacin showed no chondrotoxicity for the cartilages and, in some but not all animals, reduced haemorrhage and neutrophil infiltration in the tympanic cavity, compared with that of the control. Further, the articular cartilage of the humeral trochlea and femoral condyle also showed no change.
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This article has been cited by other articles:


Home page
 Arch Otolaryngol Head Neck SurgHome page
R. N. Jones, J. Milazzo, and M. Seidlin
Ofloxacin Otic Solution for Treatment of Otitis Externa in Children and Adults
Arch Otolaryngol Head Neck Surg, November 1, 1997; 123(11): 1193 - 1200.
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