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Journal of Antimicrobial Chemotherapy, Vol 39, 261-264, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

JOURNAL ARTICLE

Novel antifungal agents which inhibit lanosterol 14alpha-demethylase in Candida albicans CCH442 [published erratum appears in J Antimicrob Chemother 1998 Jun;41(6):671]

D Zakula, JO Capobianco and RC Goldman
Anti-infective Research Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA.

We have identified four non-azole inhibitors of lanosterol 14a- demethylase in Candida albicans CCH442. The most potent compound, A- 39806, had IC50 values for ergosterol inhibition of 0.9 microM (0.3 mg/L) and 1.9 microM (0.6 mg/L) in whole cell and cell-free extract assays, respectively. A-39806 demonstrated broad in-vitro antifungal activity against several Candida species as well as against Cryptococcus albidus and Aspergillus niger. In-vitro antifungal activity was also demonstrated against a fluconazole-resistant clinical isolate of C. albicans.
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